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Article

Barrier activity in Candida albicans mediates pheromone degradation and promotes mating.

Eukaryotic cell - 1 Jun 2007

Schaefer Dana, Côte Pierre, Whiteway Malcolm, Bennett Richard J

Abstract excerpt

Mating in Candida albicans and Saccharomyces cerevisiae is regulated by the secretion of peptide pheromones that initiate the mating process. An important regulator of pheromone activity in S. cerevisiae is barrier activity, involving an extracellular aspartyl protease encoded by the BAR1 gene that degrades the alpha pheromone. We have characterized an equivalent barrier activity in C. albicans and demonstrate...

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Identifiers

PMID: 17416895
DOI: 10.1128/EC.00090-07
PMCID: PMC1951518

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