Article
Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression.
AIDS (London, England) - 23 Apr 2007
Gulick Roy M, Lalama Christina M, Ribaudo Heather J, Shikuma Cecilia M, Schackman Bruce R, Schouten Jeffrey, Squires Kathleen E, Koletar Susan L, Pilcher Christopher D, Reichman Richard C, Klingman Karin L, Kuritzkes Daniel R
Abstract excerpt
OBJECTIVE: To compare a quadruple-nucleoside with an efavirenz-containing regimen for treatment of HIV-1 infection. DESIGN: A randomized, open-label study of the AIDS Clinical Trials Group (ACTG). METHODS: Subjects receiving zidovudine/lamivudine/abacavir on ACTG 5095 with HIV-1 RNA less than 200 copies/ml were randomly assigned to intensify either with tenofovir or efavirenz. Subjects were followed for time to...
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