Article
Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection.
The New England journal of medicine - 11 Dec 2003
Shafer Robert W, Smeaton Laura M, Robbins Gregory K, De Gruttola Victor, Snyder Sally W, D'Aquila Richard T, Johnson Victoria A, Morse Gene D, Nokta Mostafa A, Martinez Ana I, Gripshover Barbara M, Kaul Pamposh, Haubrich Richard, Swingle Mary, McCarty S Debra, Vella Stefano, Hirsch Martin S, Merigan Thomas C
Abstract excerpt
BACKGROUND: It is unclear whether therapy for human immunodeficiency virus type 1 (HIV-1) should be initiated with a four-drug or two sequential three-drug regimens. METHODS: In this multicenter trial we compared initial therapy involving four-drug regimens containing efavirenz and nelfinavir in combination with either didanosine and stavudine or zidovudine and lamivudine with therapy involving two consecutive...
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