Article
A randomized, placebo-controlled trial of abacavir intensification in HIV-1-infected adults with virologic suppression on a protease inhibitor-containing regimen.
HIV clinical trials - 1 Jan 2000
Hammer Scott M, Ribaudo Heather, Bassett Roland, Mellors John W, Demeter Lisa M, Coombs Robert W, Currier Judith, Morse Gene D, Gerber John G, Martinez Ana I, Spreen William, Fischl Margaret A, Squires Kathleen E
Abstract excerpt
BACKGROUND AND OBJECTIVE: Maximizing the durability of viral suppression is a key goal of antiretroviral therapy. The objective of AIDS Clinical Trials Group Study 372A was to determine whether the intensification strategy of adding abacavir to an effective indinavir-dual nucleoside regimen would delay the time to virologic failure. METHODS: Zidovudine-experienced subjects (n=229) on therapy with indinavir +...
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