Increased cell hydration promotes both tumor growth and metastasis: a biochemical mechanism consistent with genetic signatures.

Abstract excerpt

It was postulated previously that a progressive increase in cell hydration, induced by successive genetic or epigenetic changes, is the basic mechanism of multistep carcinogenesis, and also that the degree of malignancy increases with the degree of cell hydration. These hypotheses implied that increased cell hydration is a common factor promoting both tumor growth and metastasis, and that metastatic potential...

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