Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pydA-pydB fusion gene produces an active dioxygenase-hydrolase that degrades 3-hydroxy-4-pyridone, an intermediate of mimosine metabolism.

Applied microbiology and biotechnology - 1 Jun 2007

Awaya Jonathan D, Walton Chad, Borthakur Dulal

Abstract excerpt

The objective of this research was to construct a pydA-pydB hybrid gene that encodes a functional dioxygenase-hydrolase (PydA-PydB) fusion protein for degradation of 3-hydroxy-4-pyridone (HP). HP is an intermediate in both synthesis and degradation of mimosine, a toxic amino acid produced by the tree legume Leucaena leucocephala. Computer-generated models of the fusion proteins suggested that joining of PydA and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dioxygenases
Share to Fabaceae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Hydrolases

Share to Pyridones

Share to Recombinant Fusion Proteins

Share to Rhizobium

Share to Structural Homology, Protein

Source

Identifiers

PMID: 17390132
DOI: 10.1007/s00253-007-0858-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The pydA-pydB fusion gene produces an active dioxygenase-hydrolase that degrades 3-hydroxy-4-pyridone, an intermediate of mimosine metabolism.PMID 17390132Read ↗

The mid genes of Rhizobium sp strain TAL1145 are required for degradation of mimosine into 3-hydroxy-4-pyridone and are inducible by mimosine.Semantic proximity Read ↗

A nonribosomal peptide synthase containing a stand-alone condensation domain is essential for phytotoxin zeamine biosynthesis.Semantic proximity Read ↗

dpp genes of Rhizobium leguminosarum specify uptake of delta-aminolevulinic acid.Semantic proximity Read ↗

Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: characterization of the lys7 gene encoding saccharopine reductase.Semantic proximity Read ↗

L,L-diaminopimelate aminotransferase from Chlamydomonas reinhardtii: a target for algaecide development.Semantic proximity Read ↗

Amino acid alterations essential for increasing the catalytic activity of the nylon-oligomer-degradation enzyme of Flavobacterium sp.Semantic proximity Read ↗

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS EngineeringSemantic proximity Read ↗

Pyrrolizwilline, a Unique Bacterial Alkaloid Assembled by a Nonribosomal Peptide Synthetase and non‐Enzymatic DimerizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.