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Article

Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen.

1 Feb 1992

Abstract excerpt

To characterize the autoantigen of Goodpasture's (anti-glomerular basement membrane) disease, a molecule of 26-kD reactive with autoantibodies from patients' sera was purified from collagenase digests of sheep glomerular basement membrane. Short internal amino acid sequences were obtained after tryptic or cyanogen bromide cleavage, and used to deduce redundant oligonucleotides for use in the polymerase chain...

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Identifiers

PMID: 1737849
DOI: 10.1172/jci115625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen.PMID 1737849Read ↗

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Patients with Goodpasture's disease have two normal COL4A3 alleles encoding the NC1 domain of the type IV collagen alpha 3 chain.Semantic proximity Read ↗

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Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies.Semantic proximity Read ↗

Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells.Semantic proximity Read ↗

Sequence and localization of a partial cDNA encoding the human alpha 3 chain of type IV collagen.Semantic proximity Read ↗

Goodpasture Antigen-binding Protein, the Kinase That Phosphorylates the Goodpasture Antigen, Is an Alternatively Spliced Variant Implicated in Autoimmune PathogenesisSemantic proximity Read ↗

Quaternary Organization of the Goodpasture Autoantigen, the α3(IV) Collagen ChainSemantic proximity Read ↗

New Nomenclature for the Human Tissue Kallikrein Gene FamilySemantic proximity Read ↗

The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen.Semantic proximity Read ↗

Colocalization of the genes for the α3(IV) and α4(IV) chains of type IV collagen to chromosome 2 bands q35–q37Semantic proximity Read ↗

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