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Article

The Goodpasture Autoantigen

1 Feb 2000

Abstract excerpt

Goodpasture (GP) disease is an autoimmune disorder in which autoantibodies against the alpha3(IV) chain of type IV collagen bind to the glomerular and alveolar basement membranes, causing progressive glomerulonephritis and pulmonary hemorrhage. Two major conformational epitope regions have been identified on the noncollagenous domain of type IV collagen (NC1 domain) of the alpha3(IV) chain as residues 17-31...

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Identifiers

PMID: 10681598
DOI: 10.1074/jbc.275.8.6030

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