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Article

Selection for functional diversity drives accumulation of point mutations in Dr adhesins of Escherichia coli.

Molecular microbiology - 1 Apr 2007

Korotkova Natalia, Chattopadhyay Sujay, Tabata Tami A, Beskhlebnaya Viktoria, Vigdorovich Vladimir, Kaiser Brett K, Strong Roland K, Dykhuizen Daniel E, Sokurenko Evgeni V, Moseley Steve L

Abstract excerpt

Immune escape is considered to be the driving force behind structural variability of major antigens on the surface of bacterial pathogens, such as fimbriae. In the Dr family of Escherichia coli adhesins, structural and adhesive functions are carried out by the same subunit. Dr adhesins have been shown to bind decay-accelerating factor (DAF), collagen IV, and carcinoembryonic antigen-related cell adhesion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17376081
DOI: 10.1111/j.1365-2958.2007.05648.x

Genes

CEACAM3
CEACAM6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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