Article
Hypoxic adaptations of hemoglobin in Tibetan chick embryo: high oxygen-affinity mutation and selective expression.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Jun 2007
Gou Xiao, Li Ning, Lian Linsheng, Yan Dawei, Zhang Hao, Wei Zhehui, Wu Changxin
Abstract excerpt
Tibetan chicks (Gallus gallus) survived with high hatchability (35.0%) and Recessive White Feather broilers (RWF) from low elevations survived rarely and with a low hatchability (3.0%) after simulated incubation under hypoxia of 13% O2. The functional mutation of Met-32D(B13)-Leu of alpha(D) globin chain was related with hypoxia based on allele distribution, homology model building and oxygen affinity assay....
Topics
- Adaptation, Physiological
- Animals
- Base Sequence
- Chick Embryo
- Chickens
- DNA Primers
- Gene Expression
- Hemoglobins
- Hypoxia
- Molecular Sequence Data
- Mutation