Article
Phenotype selection for detecting variable genes: a survey of cardiovascular quantitative traits and TNF locus polymorphism.
European journal of human genetics : EJHG - 1 Jun 2007
Hong Mun-Gwan, Bennet Anna M, de Faire Ulf, Prince Jonathan A
Abstract excerpt
The practice of using discrete clinical diagnoses in genetic association studies has seldom led to a replicable genetic model. If, as the literature suggests, weak genotype-phenotype relationships are detected when clinical diagnoses are used, power might be increased by exploring more fundamenta...
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