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Article

Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Aug 2004

Montanelli Lucia, Van Durme Joost J J, Smits Guillaume, Bonomi Marco, Rodien Patrice, Devor Eric J, Moffat-Wilson Kristin, Pardo Leonardo, Vassart Gilbert, Costagliola Sabine

Abstract excerpt

Recently, three naturally occurring mutations in the serpentine region of the FSH receptor (FSHr) (D567N and T449I/A) have been identified in three families with spontaneous ovarian hyperstimulation syndrome (OHSS). All mutant receptors displayed abnormally high sensitivity to human chorionic gon...

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Identifiers

PMID: 15166252
DOI: 10.1210/me.2004-0036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15166252-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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