Article
Should pharmacogenomic studies be required for new drug approval?
Clinical pharmacology and therapeutics - 1 Mar 2007
Relling M V, Hoffman J M
Abstract excerpt
The field of pharmacogenetics has existed since the 1950s, when it was demonstrated that some drug effects could differ substantially among race and ethnic groups, and that some drug metabolizing enzyme activities were inherited. During the 1990s, application of molecular biology to the study of inherited drug-related phenotypes proved the genetic basis of several genetic polymorphisms. Genomic technology has now...
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