[Highly sensitive systems for experimental insertional mutagenesis in repair-deficient genetic environment in Drosophila melanogaster: new opportunities for studying postreplication repair of double-stranded DNA breaks and mechanisms of transposable element migration].

Abstract excerpt

Spontaneous mutations in Drosophila melanogaster are related mainly to transposable elements (TEs). They are caused by both migration of TEs over the genome (transpositions) and the ability of TEs to induce chromosomal mutations. Migration of DNA transposons is accompanied by formation of double-strand DNA breaks (DSBs), which are repaired by host repair systems encoded by genes for recombination repair. We...

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