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Article

No Evidence for Mouse Pancreatic β-Cell Epithelial-Mesenchymal Transition In Vitro

27 Feb 2007

Abstract excerpt

We used cre/loxP-based genetic lineage tracing analysis to test a previously proposed hypothesis that in vitro cultured adult pancreatic beta-cells undergo epithelial-mesenchymal transition (EMT) to generate a highly proliferative, differentiation-competent population of mesenchymal islet "progenitor" cells. Our results in the mouse that are likely to be directly relevant to the human system show that adult mouse...

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Identifiers

PMID: 17327438
DOI: 10.2337/db06-1446

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