Article
Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease.
Human molecular genetics - 15 Apr 2007
Baessler Andrea, Fischer Marcus, Mayer Bjoern, Koehler Martina, Wiedmann Silke, Stark Klaus, Doering Angela, Erdmann Jeanette, Riegger Guenter, Schunkert Heribert, Kwitek Anne E, Hengstenberg Christian
Abstract excerpt
Data from both experimental models and humans provide evidence that ghrelin and its receptor, the growth hormone secretagogue receptor (ghrelin receptor, GHSR), possess a variety of cardiovascular effects. Thus, we hypothesized that genetic variants within the ghrelin system (ligand ghrelin and i...
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