Article
Combination of linkage and association studies for brain arteriovenous malformation.
Stroke - 1 Apr 2007
Inoue Sumiko, Liu Wanyang, Inoue Kayoko, Mineharu Youhei, Takenaka Katsunobu, Yamakawa Hiroyasu, Abe Masamitsu, Jafar Jafar J, Herzig Roman, Koizumi Akio
Abstract excerpt
BACKGROUND AND PURPOSE: Genetic factors for brain arteriovenous malformation are unexplored because of the low incidence of familial cases, albeit local and familial clustering. We used a combination of a linkage study and an association study to explore the genetic background. METHODS: A genome-wide linkage analysis was performed in 12 patients from 6 unrelated families using the GENEHUNTER program. A...
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