Article
Linkage analysis of chromosome 4 in families with familial pancreatic cancer.
Cancer biology & therapy - 1 Mar 2007
Klein Alison P, de Andrade Mariza, Hruban Ralph H, Bondy Melissa, Schwartz Ann G, Gallinger Steven, Lynch Henry T, Syngal Sapna, Rabe Kari G, Goggins Michael G, Petersen Gloria M
Abstract excerpt
BACKGROUND: Approximately 10% of pancreatic ductal adenocarcinomas have a familial basis. While a small portion of this familial clustering can be explained by inherited mutations in known genes (BRCA2, p16/CDKN2A, PRSS1, and STK11), the genetic basis for the majority of this familial clustering remains unknown. In addition, a pancreatic cancer susceptibility locus has been reported to be linked to chromosome...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.