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Article

Yeast casein kinase I homologues: an essential gene pair.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1992

Robinson L C, Hubbard E J, Graves P R, DePaoli-Roach A A, Roach P J, Kung C, Haas D W, Hagedorn C H, Goebl M, Culbertson M R

Abstract excerpt

We report the isolation of an essential pair of Saccharomyces cerevisiae genes that encode protein kinase homologues. The two genes were independently isolated as dosage-dependent suppressors. Increased dosage of YCK1 suppressed defects caused by reduced SNF1 protein kinase activity, and increased dosage of YCK2 relieved sensitivity of wild-type cells to salt stress. The two genes function identically in the two...

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Identifiers

PMID: 1729698
DOI: 10.1073/pnas.89.1.28
PMCID: PMC48168

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