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Article

A cytosolic trans-activation domain essential for ammonium uptake.

Nature - 8 Mar 2007

Loqué D, Lalonde S, Looger L L, von Wirén N, Frommer W B

Abstract excerpt

Polytopic membrane proteins are essential for cellular uptake and release of nutrients. To prevent toxic accumulation, rapid shut-off mechanisms are required. Here we show that the soluble cytosolic carboxy terminus of an oligomeric ammonium transporter from Arabidopsis thaliana serves as an allosteric regulator essential for function; mutations in the C-terminal domain, conserved between bacteria, fungi and...

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Source

Identifiers

PMID: 17293878
DOI: 10.1038/nature05579

Genes

AMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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