Article
Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains.
The Journal of general virology - 1 Dec 2009
Hall Roy A, Tan Si En, Selisko Barbara, Slade Rachael, Hobson-Peters Jody, Canard Bruno, Hughes Megan, Leung Jason Y, Balmori-Melian Ezequiel, Hall-Mendelin Sonja, Pham Kim B, Clark David C, Prow Natalie A, Khromykh Alexander A
Abstract excerpt
The West Nile virus (WNV) NS5 protein contains a methyltransferase (MTase) domain involved in RNA capping and an RNA-dependent RNA polymerase (RdRp) domain essential for virus replication. Crystal structures of individual WNV MTase and RdRp domains have been solved; however, the structure of full-length NS5 has not been determined. To gain more insight into the structure of NS5 and interactions between the MTase...
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