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Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.

Stem cells (Dayton, Ohio) - 1 Feb 2007

Rajesh Deepika, Chinnasamy Nachimuthu, Mitalipov Shoukhrat M, Wolf Don P, Slukvin Igor, Thomson James A, Shaaban Aimen F

Abstract excerpt

Progress toward clinical application of ESC-derived hematopoietic cellular transplantation will require rigorous evaluation in a large animal allogeneic model. However, in contrast to human ESCs (hESCs), efforts to induce conclusive hematopoietic differentiation from rhesus macaque ESCs (rESCs) have been unsuccessful. Characterizing these poorly understood functional differences will facilitate progress in this...

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PMID: 17284653
DOI: 10.1634/stemcells.2006-0277

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