Article
Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk.
Cancer research - 1 Feb 2007
Hemminki Kari, Ji Jianguang, Försti Asta
Abstract excerpt
The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and...
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