Article
Ancestral alleles and population origins: inferences depend on mutation rate.
Molecular biology and evolution - 1 Apr 2007
Rogers Alan R, Wooding Stephen, Huff Chad D, Batzer Mark A, Jorde Lynn B
Abstract excerpt
Previous studies have found that at most human loci, ancestral alleles are "African," in the sense that they reach their highest frequency there. Conventional wisdom holds that this reflects a recent African origin of modern humans. This paper challenges that view by showing that the empirical pattern (of elevated allele frequencies within Africa) is not as pervasive as has been thought. We confirm this African...
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