Article
In vivo and in vitro anaerobic mating in Candida albicans.
Eukaryotic cell - 1 Mar 2007
Dumitru Raluca, Navarathna Dhammika H M L P, Semighini Camile P, Elowsky Christian G, Dumitru Razvan V, Dignard Daniel, Whiteway Malcolm, Atkin Audrey L, Nickerson Kenneth W
Abstract excerpt
Candida albicans cells of opposite mating types are thought to conjugate during infection in mammalian hosts, but paradoxically, the mating-competent opaque state is not stable at mammalian body temperatures. We found that anaerobic conditions stabilize the opaque state at 37 degrees C, block production of farnesol, and permit in vitro mating at 37 degrees C at efficiencies of up to 84%. Aerobically, farnesol...
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