Article
Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia.
Experimental hematology - 1 Feb 2007
Blau Olga, Hofmann Wolf-Karsten, Baldus Claudia Dorothea, Thiel Gundula, Serbent Verena, Schümann Elke, Thiel Eckhard, Blau Igor Wolfgang
Abstract excerpt
OBJECTIVE: Bone marrow mesenchymal stroma cells (BMSC) are key components of the hematopoietic microenvironment. The question of whether BMSC from patients with hematological disorders have cytogenetic abnormalities is discussed controversially, some studies indicating that they are cytogenetically normal and others providing evidence of their aberrations. PATIENTS AND METHODS: We performed standard and molecular...
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