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Article

PTEN-Mediated Resistance to Epidermal Growth Factor Receptor Kinase Inhibitors

15 Jan 2007

Abstract excerpt

Molecularly targeted therapies are transforming the treatment of cancer. Elucidating the dynamic signaling networks that underlie sensitivity and resistance to these inhibitors is critical for successful clinical application. There is considerable evidence to suggest that constitutively activating mutations in kinases that regulate cellular growth may result in tumor cell "addiction" and favorable response to...

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Identifiers

PMID: 17255257
DOI: 10.1158/1078-0432.ccr-06-1992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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