Article
Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.
Journal of neuroscience research - 1 Mar 2007
Caballero Cristina, Jimenez Sebastian, Moreno-Gonzalez Ines, Baglietto-Vargas David, Sanchez-Varo Raquel, Gavilan M Paz, Ramos Blanca, Del Rio Juan Carlos, Vizuete Marisa, Gutierrez Antonia, Ruano Diego, Vitorica Javier
Abstract excerpt
The detection of the early phenotypic modifications of Alzheimer's disease (AD) models is fundamental to understand the progression and identify pharmacologic targets of this pathology. However, a large variability within different models and between age-matched mice from the same model has been...
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