Article
Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C.
Gastroenterology - 1 Jan 2007
Shiffman Mitchell L, Ghany Marc G, Morgan Timothy R, Wright Elizabeth C, Everson Gregory T, Lindsay Karen L, Lok Anna S F, Bonkovsky Herbert L, Di Bisceglie Adrian M, Lee William M, Dienstag Jules L, Gretch David R
Abstract excerpt
BACKGROUND & AIMS: Reducing the dose of peginterferon and/or ribavirin to <80% when treating chronic hepatitis C virus has been associated with a reduction in sustained virologic response (SVR). However, prior studies did not assess the impact of reducing the dose of peginterferon independent of ribavirin or differentiate between dose reduction or interrupting or prematurely discontinuing treatment. METHODS: Nine...
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