Article
On the pharmacological phenocopying of memory mutations in Drosophila: alkylxanthines accelerate memory decay.
Behavior genetics - 1 Sept 1991
Asztalos Z, Lossos M, Friedrich P
Abstract excerpt
Theophylline and 3-isobutyl-1-methylxanthine, two cyclic nucleotide phosphodiesterase inhibitors, when fed to wild-type Drosophila adults, cause the rapid decay of learning index after training in a shock-odor learning paradigm. The drugs practically do not affect the olfactory acuity of flies, hence they influence the learning/memory process itself. The time courses of memory decay resemble those of the memory...
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