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Article

Analysis of topoisomerase mutations in fluoroquinolone-resistant and -susceptible Campylobacter jejuni strains isolated in Senegal.

International journal of antimicrobial agents - 1 Apr 2007

Kinana Alfred Dieudonné, Cardinale Eric, Bahsoun Ibrahim, Tall Fatou, Sire Jean-Marie, Garin Benoit, Boye Cheikh Saad-Bouh, Dromigny Jacques-Albert, Perrier-Gros-Claude Jean-David

Abstract excerpt

In this study, topoisomerase mutations in ciprofloxacin-resistant and -susceptible Campylobacter jejuni were analysed by DNA sequencing. In certain ciprofloxacin-resistant C. jejuni, the mechanism of resistance was complex. The Thr86-Ala substitution in the GyrA protein appears to play a role in increasing the minimum inhibitory concentration of nalidixic acid only. In addition, isolates with this amino acid...

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PMID: 17224260
DOI: 10.1016/j.ijantimicag.2006.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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