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Article

Combinatorial epigenetics, "junk DNA", and the evolution of complex organisms.

Gene - 1 Apr 2007

Zuckerkandl Emile, Cavalli Giacomo

Abstract excerpt

At certain evolutionary junctures, two or more mutations participating in the build-up of a new complex function may be required to become available simultaneously in the same individuals. How could this happen in higher organisms whose populations are small compared to those of microbes, and in which chances of combined nearly simultaneous highly specific favorable mutations are correspondingly low? The question...

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Identifiers

PMID: 17223284
DOI: 10.1016/j.gene.2006.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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