Article
Effect of superoxide dismutase gene inactivation on virulence of Pseudomonas aeruginosa PAO1 toward the silkworm, Bombyx mori.
Applied and environmental microbiology - 1 Mar 2007
Iiyama Kazuhiro, Chieda Yuuka, Lee Jae Man, Kusakabe Takahiro, Yasunaga-Aoki Chisa, Shimizu Susumu
Abstract excerpt
To investigate the role of superoxide dismutase (SOD) in virulence against the silkworm, Bombyx mori, mutants of Pseudomonas aeruginosa PAO1 lacking manganese-SOD (PAO1sodM), iron-SOD (PAO1sodB), or both (PAO1sodMB) were generated. The mutants were injected into the hemocoel of B. mori. The virulence decreased in the order PAO1=PAO1sodM>PAO1sodB>PAO1sodMB. In particular, PAO1sodMB was avirulent at a dose of 10(5)...
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