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Article

Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.

Cell - 12 Jan 2007

Keays David A, Tian Guoling, Poirier Karine, Huang Guo-Jen, Siebold Christian, Cleak James, Oliver Peter L, Fray Martin, Harvey Robert J, Molnár Zoltán, Piñon Maria C, Dear Neil, Valdar William, Brown Steve D M, Davies Kay E, Rawlins J Nicholas P, Cowan Nicholas J, Nolan Patrick, Chelly Jamel, Flint Jonathan

Abstract excerpt

The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex,...

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Identifiers

PMID: 17218254
DOI: 10.1016/j.cell.2006.12.017
PMCID: PMC1885944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.PMID 17218254Read ↗

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