Article
Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.
The Journal of biological chemistry - 9 Mar 2007
Yamashita Daisuke, Komori Hirofumi, Higuchi Yoshiki, Yamaguchi Tomohiro, Osumi Takashi, Hirose Fumiko
Abstract excerpt
We previously demonstrated that hDREF, a human homologue of Drosophila DNA replication-related element binding factor (dDREF), is a DNA-binding protein predominantly distributed with granular structures in the nucleus. Here, glutathione S-transferase pulldown and chemical cross-linking assays showed that the carboxyl-terminal hATC domain of hDREF, highly conserved among hAT transposase family members, possesses...
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