Article
Identification of an amyloidogenic region on keratoepithelin via synthetic peptides.
FEBS letters - 23 Jan 2007
Yuan Ching, Berscheit Heather L, Huang Andrew J W
Abstract excerpt
Mutations of keratoepithelin (KE) gene in human chromosome 5q31 have been linked with corneal epithelial or stromal dystrophies characterized by the abnormal deposits of amyloid fibrils and/or non-amyloid aggregations in corneal tissue. We report herein that synthetic peptide containing amino acid (a.a.) residues of 515-532 of native KE protein can readily form beta-sheet-containing amyloid fibrils in vitro....
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