Article
Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.
Molecular vision - 20 Dec 2006
Horie Yukihiro, Takemoto Yuko, Miyazaki Akiko, Namba Kenichi, Kase Satoru, Yoshida Kazuhiko, Ota Masao, Hasumi Yukiko, Inoko Hidetoshi, Mizuki Nobuhisa, Ohno Shigeaki
Abstract excerpt
PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)). METHODS: 87 VKH patients and 122 healthy controls were genotyped using seven microsatellite markers on the candidate loci. We analyzed microsatellite (MS) polymorphisms at regions within...
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