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Article

Copper- and iron-rich matrices in hepatocellular lipofuscin particles of a young male patient: diagnostic ultrastructures for Wilson disease.

Ultrastructural pathology - 1 Jan 2000

Motonishi Satoshi, Hayashi Hisao, Fujita Yoshikazu, Okada Hidetoshi, Kusakabe Atsuhiko, Ito Masafumi, Miyamoto Kenichi, Ueno Toshio

Abstract excerpt

A 17-year-old male patient appeared with the biochemical liver damage associated with hypoceruloplasminemia and mild iron overload. Genetic analysis identified a compound heterozygosity of ATP7B responsible for the primary copper toxicosis of Wilson disease without mutations in HFE. A liver specimen consisted of cirrhotic nodules of large-sized hepatocytes with fatty change and those of fat-free small-sized...

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Source

Identifiers

PMID: 17182432
DOI: 10.1080/01913120600854327

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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