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Article

High conservation of sequences involved in cystic fibrosis mutations in five mammalian species.

Genomics - 1 Aug 1991

Gasparini P, Nunes V, Dognini M, Estivill X

Abstract excerpt

Several mutations have been identified in the first nucleotide binding fold (NBF) of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene. We have analyzed the DNA sequences of exons 10 and 11 in five different mammalian species, marmoset, mouse, cow, pig, and sheep; the amino acid conservation studied for nine disease mutations; and two "benign" mutations. For exon 10, 87% homology at the DNA...

Topics

Amino Acid Sequence
Animals
Base Sequence
Callithrix
Cattle
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Exons
Humans
Membrane Proteins
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligodeoxyribonucleotides

Sequence Homology, Nucleic Acid

Sheep

Swine

Source

Identifiers

PMID: 1717363
DOI: 10.1016/0888-7543(91)90200-x

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717363-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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