Stress-induced expression of the Escherichia coli phage shock protein operon is dependent on sigma 54 and modulated by positive and negative feedback mechanisms.

Abstract excerpt

The phage shock protein (psp) operon of Escherichia coli is strongly induced in response to heat, ethanol, osmotic shock, and infection by filamentous bacteriophages. The operon contains at least four genes--pspA, pspB, pspC, and pspE--and is regulated at the transcriptional level. We report here that psp expression is controlled by a network of positive and negative regulatory factors and that transcription in...

Topics

• Bacterial Proteins
• Base Sequence
• Chromosome Deletion
• Chromosomes, Bacterial
• Coliphages
• Escherichia coli
• Escherichia coli Proteins
• Feedback
• Gene Expression Regulation, Bacterial
• Genes, Bacterial