Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production.

doi:10.1002/jcp.20952

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Article

Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production.

Journal of cellular physiology - 1 May 2007

Catalano Stefania, Rizza Pietro, Gu Guowei, Barone Ines, Giordano Cinzia, Marsico Stefania, Casaburi Ivan, Middea Emilia, Lanzino Marilena, Pellegrino Michele, Andò Sebastiano

Abstract excerpt

The testis is an immunologically privileged site of the body where Sertoli cells work on to favor local immune tolerance by testicular autoantigens segregation and immunosuppressive factors secretion. Fas/Fas Ligand (FasL) system, expressed prevalently in Sertoli cells, has been considered to be one of the central mechanisms in testis immunological homeostasis. In different cell lines it has been reported that...

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PMID: 17167783
DOI: 10.1002/jcp.20952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.