Article
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras.
Journal of medicinal chemistry - 14 Dec 2006
Tejada Frederick R, Nagy Peter I, Xu Min, Wu Cindy, Katz Tricia, Dorsey Jason, Rieman Melissa, Lawlor Elizabeth, Warrier Manya, Messer William S
Abstract excerpt
As part of a continuing effort to design and synthesize highly selective muscarinic agonists for different muscarinic receptor subtypes, several tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (1) analogues were prepared and characterized. Different analogues were synthesized having hydrophilic spacers of di-, tri-, tetra-,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.