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Article

The dopamine D4 receptor gene and moderation of the association between externalizing behavior and IQ.

Archives of general psychiatry - 1 Dec 2006

DeYoung Colin G, Peterson Jordan B, Séguin Jean R, Mejia Jose Maria, Pihl Robert O, Beitchman Joseph H, Jain Umesh, Tremblay Richard E, Kennedy James L, Palmour Roberta M

Abstract excerpt

BACKGROUND: Dopaminergic neurotransmission is implicated in externalizing behavior problems, such as aggression and hyperactivity. Externalizing behavior is known to be negatively associated with cognitive ability. Activation of dopamine D4 receptors appears to inhibit the functioning of the prefrontal cortex, a brain region implicated in cognitive ability. The 7-repeat allele of the dopamine D4 receptor gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17146015
DOI: 10.1001/archpsyc.63.12.1410
PMCID: PMC3283582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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