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Article

HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction.

Circulation - 19 Dec 2006

Park Sung Kyun, O'Neill Marie S, Wright Robert O, Hu Howard, Vokonas Pantel S, Sparrow David, Suh Helen, Schwartz Joel

Abstract excerpt

BACKGROUND: Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associated with increased...

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Source

Identifiers

PMID: 17145987
DOI: 10.1161/CIRCULATIONAHA.106.643197

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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