Article
Polymorphism of HLA-DR and HLA-DQ in rheumatoid arthritis patients and clinical response to methotrexate--a hospital-based study.
JPMA. The Journal of the Pakistan Medical Association - 1 Oct 2006
Ali Azra Arif I, Moatter Tariq, Baig Jawed Altaf, Iqbal Ahmed, Hussain Azmat, Iqbal Mohammad Perwaiz
Abstract excerpt
OBJECTIVE: To investigate the frequency and distribution of DRB1 and DQB1 alleles in Patients with rheumatoid arthritis (RA) and analyze the relationship between clinical response to methotrexate (MTX) and the HLA-DR and HLA-DQ genotypes in these patients. METHODS: In this case-control study, the HLA-DRB1 and HLA-DQB1 polymorphism in 91 RA patients and 91 healthy controls was done using polymerase chain reaction...
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