Article
Combinational effect of genes for the renin-angiotensin system in conferring susceptibility to diabetic nephropathy.
Journal of human genetics - 1 Jan 2007
Osawa Norihisa, Koya Daisuke, Araki Shin-Ichi, Uzu Takashi, Tsunoda Tatsuhiko, Kashiwagi Atsunori, Nakamura Yusuke, Maeda Shiro
Abstract excerpt
To elucidate the role of the renin-angiotensin system (RAS) in diabetic nephropathy, we examined the association between diabetic nephropathy in a large cohort of Japanese type 2 diabetic patients and polymorphisms within the genes that encode angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II receptor type 1 (AGTR1). Single nucleotide polymorphisms (SNPs) within these genes were...
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