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Article

Evidence regarding a stem cell origin of hepatocellular carcinoma.

Stem cell reviews - 1 Jan 2005

Shupe Thomas, Petersen Bryon E

Abstract excerpt

The cellular origin of tumors remains as one of the unanswered, fundamental questions of cancer biology. The notion that tumors may arise from tissue stem cells is supported by phenotypic similarities between these two cell types, such as proliferative potential and expression of onco-fetal proteins. Liver stem cells, or oval cells, have been put forth as a possible target for hepatocarcinogens. Genetically...

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Identifiers

PMID: 17142863
DOI: 10.1385/SCR:1:3:261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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