Article
The genetic spectrum of a population-based sample of familial hemiplegic migraine.
Brain : a journal of neurology - 1 Feb 2007
Thomsen L L, Kirchmann M, Bjornsson A, Stefansson H, Jensen R M, Fasquel A C, Petursson H, Stefansson M, Frigge M L, Kong A, Gulcher J, Stefansson K, Olesen J
Abstract excerpt
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. FHM mutations are known in three genes, the CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) gene and seem to have an autosomal-dominant mode of inheritance. The aim of this study was to search for FHM mutations in FHM families identified through a screen of the Danish population of 5.2 million people....
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