Article
The incidence of different cystic fibrosis mutations in the Scottish population: effects on prenatal diagnosis and genetic counselling.
Journal of medical genetics - 1 May 1991
Shrimpton A E, McIntosh I, Brock D J
Abstract excerpt
We present an analysis of the frequency of 16 different cystic fibrosis (CF) mutant alleles in the Scottish population. Each allele was detected in DNA amplified by the polymerase chain reaction (PCR) either directly on polyacrylamide gels, on agarose gels after restriction enzyme digestion, or b...
Topics
- Alleles
- Base Sequence
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- Fetal Diseases
- Gene Frequency
- Genetic Carrier Screening
- Genetic Counseling
- Genetic Markers
- Humans
- Incidence
- Membrane Proteins
- Molecular Sequence Data
- Polymerase Chain Reaction
- Prenatal Diagnosis
- Recombination, Genetic
- Risk Factors