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Article

CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features.

Blood - 1 Apr 2007

Karube Kennosuke, Guo Ying, Suzumiya Junji, Sugita Yasuo, Nomura Yuko, Yamamoto Kohei, Shimizu Kei, Yoshida Shirou, Komatani Hideki, Takeshita Morishige, Kikuchi Masahiro, Nakamura Naoya, Takasu Osamu, Arakawa Fumiko, Tagawa Hiroyuki, Seto Masao, Ohshima Koichi

Abstract excerpt

CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation,...

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Share to Somatic Hypermutation, Immunoglobulin

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Source

Identifiers

PMID: 17138820
DOI: 10.1182/blood-2006-09-045989

Genes

BCL2
BCL6
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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